Masaryk University GRADE Center

The Grading of Recommendations Assessment, Development and Evaluation (short GRADE) is an informal collaboration of people with an interest in addressing the shortcomings of grading systems in healthcare. GRADE is a common, sensible and transparent approach to grading quality (or certainty) of evidence and strength of recommendations. Many international organizations have provided input into the development of the GRADE approach which is now considered the standard in guideline development. Because of the project “Clinical Practice Guidelines” (project number: CZ.03.2.63/0.0/0.0/15_039/0008221) where GRADE approach is used, Masaryk University GRADE centre was established to help to promote the GRADE approach in the Czech Republic.

Masaryk University GRADE centre was founded in December 2018 and officially opened at the conference “European JBI symposium of EBHC in Clinical Practice Guidelines” with a founder of the GRADE working group Prof.Schűnemann, with the director of the Masaryk University GRADE centre Dr Klugar, Deputy Directors Dr Klugarová and Prof. Pokorná, who as a Vice-Dean represented the Faculty of Medicine Masaryk University, within which is the center established.

The main goal of this center is education, support, dissemination, and implementation of GRADE methodological approach in the development of CPG (Clinical Practice Guidelines) and systematic review across the professional community in the Czech Republic and Central Europe.

The GRADE methodology is particularly well known through trustworthy and Evidence-Based principles based on clinical recommendations procedures. The cornerstone of The GRADE methodology is the formulation of guideline questions, creation of very wide multidisciplinary panel, identifying priority outputs in terms of patient preferences, identification and critical evaluation of relevant systematic review (in case of their absence – their creation), classification of the quality of scientific evidence and determine their strength on the basic of which can be formulated Evidence-Based Recommendations for Practice.

Transparent documentation and supporting each step during the creation of the CPG is obviousness within the methodology of GRADE. However, the GRADE methodology is also used in the creation of recommendations for practice within the systematic reviews.

Representatives of the Masaryk University GRADE centre are very significant involved in the development of the GRADE methodology because they are members of several international methodological groups. Dr. Klugar is a member of international GRADE project groups: Public Health, Evidence to Decision, Diagnostic accuracy and Overviews of reveiws. Dr. Klugar is also a member of several international project groups within the GRADE: Algorithms and pathways, Rapid guidelines, Implementation of guidelines.